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Posts tagged "microscopy"

s-c-i-guy:

Streptococcus gordonii invading host cells

The non-pathogenic non-invasive Streptococcus gordonii (red) is a common and harmless commensal bacterium of the oral human mucosa. By membrane-bound expression of the pathogenicity factor SfbI (Streptococci Fibronectin-binding Protein I) S. goordonii becomes an invasive bacterium.

Courtesy of Prof. Dr. Rohde, HZI Braunschweig

source

scienceyoucanlove:

This scanning electron microscope image of a grain of sea salt [left] and a peppercorn [right] was the winner in the 2005 Visions of Science Photographic Awards. Salt (NaCl) is essential to life as it regulates the amount of water in our bodies.

Image: David McCarthy and Annie Cavanagh

source 

s-c-i-guy:

Mouse kidney

Mouse kidney section stained with Alexa Fluor 488 wheat germ agglutinin, Alexa Fluor 568 phalloidin and DAPI.

Image courtesy of Dr. Muthugapatti Kandasamy, Director of the Biomedical Microscopy Core. University of Georgia

source

(via afro-dominicano)

biological-chemistry:

Although GFP by name, GFP can many colours other than green. These forms are entirely synthetic variations of the wild-type GFP. By doing this researchers have modified the action of GFP beyond its original activity therefore creating entirely novel protein using GFP as a precursor.

(via betterknowamicrobe)

frontal-cortex:

3D co-culture used to create a microvascular niche. Seen above are human umbilical vein endothelial cells (red immunostaining of CD31), lung fibroblasts expressing alpha-smooth muscle actin (cyan), and T4-2 breast cancer cells (green).

Weigelt & Bissell. (2014) The need for complex 3D culture models to unravel novel pathways and identify accurate biomarkers in breast cancer, Advanced Drug Delivery Reviews.

bbsrc:

The Worm Wagon

The top image in this trio shows a close up of an adult Trichuris muris, a whipworm parasite. Here the worm is seen under an electron microscope but more commonly this type of worm is seen taking residence in the large intestine of its host. 

In the second image you can see illustrations of Schistosoma mansoni by Paul Evans © 2012. This parasite lives in the blood and lays thousands of eggs which result in tissue damage and even death.

BBSRC-funded Sheena Cruickshank (centre of picture) and Professor Kathryn Else (right), are lecturers at The University of Manchester who specialise in studying parasites. Both are co-founders, with Dr Jo Pennock (left), of the outreach activity called The Worm Wagon: an exhibition that is part of the BBSRC’s 20th Anniversary Festival. This exhibit will focus on explaining how people catch infections and the global significance of these infections.

When not on the Worm Wagon their day to day research tries to understand the biology and immunology of parasite infection. Part of Sheena’s research is finding markers we can use to help diagnose patients who respond badly to infection and those who don’t. Professor Else concentrates more on vaccine research and how the damage caused by infection is regulated.

This research is vital considering the biggest killer of people under 50 is infection.

Images of Trichuris muris from Uta Rossler, Richard Grencis and Toby Starborg FLS, UoM.

Image of researchers by Mark Waugh, UoM.

For more bioscience news visit our Facebook https://www.facebook.com/bbsrcnews. Oh and don’t forget to like it! 

(via science-junkie)

mucholderthen:

generalelectric

Pictured above are the three winners of the 2013 GE Healthcare Cell Imaging Competition.

sciencenote:

13th Prize - Dr Michael Nelson and Samantha Smith

University of Alabama at Birmingham, Birmingham, Alabama, USA
Specimen: Mouse vertebra section (200x)
Technique: Focus Stacking

molecularlifesciences:

Top 5 misconceptions about evolution: A guide to demystify the foundation of modern biology.

Version 2.0

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National Center for Science Education http://ncse.com

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like-wildfire:

Drosophila Heart by Girish C. Melkani

"Amyloid-like inclusions have been associated with Huntington’s disease, and patients exhibit a high incidence of cardiovascular events. Melkani and colleagues generated a Drosophila (fruit fly) model of cardiac amyloidosis. It displays accumulation of mutant Huntingtin aggregates and oxidative stress in myocardial cells upon heart-specific expression of Huntingtin protein fragments with disease-causing poly-glutamine repeats. Using genetic manipulation, the authors showed that modulation of both protein unfolding, and oxidative stress pathways, is required to ameliorate the detrimental mutant Huntingtin defects. The image shows reduced and disorganized myosin- (pink) and actin- (cyan) containing myofibrils along with mutant Huntingtin positive aggregates (green) in the heart."

(via afro-dominicano)

s-c-i-guy:

Rat Kidney

Confocal laser scanning microscopy of rat kidney.

Tiles, stitched together with ZEN software to generate hi-res image.

source

sciencenote:

Mr. Brent Bill

Burnsville, MN, USA
Specimen: Zebrafish Embryo
Technique: Confocal

frontal-cortex:

Echiniscus mediantus (tardigrade, water bear), in various states of movement

Technique : Darkfield

Martin Mach

Mikrobiologische Vereinigung München e.V. (MVM) München, Bavaria, Germany

(via afro-dominicano)

diamidinophenylindolee:

Primary mammary epithelium in 3D Matrigel culture.

The mammary gland, which produces milk, is composed of a dense network of ducts that gradually forms after birth through a complex process of budding, invasion, and branching. At birth, the system is a rudimentary duct tree, but in response to hormones, cells in the ducts proliferate and migrate, allowing the ducts to elongate and invade through the mesenchyme layer of mammary tissue into the mammary fat pad, where they then begin to branch. Puberty brings further structural changes to the system of ducts, whereas pregnancy induces the formation of alveolar structures within the ducts for milk production.

Credit: Andrew J. Ewald, Johns Hopkins University.

beautyofmicroscopy:

A micrograph of a diatom with Rheinberg illumination.

Source: Frank Fox, http://www.mikro-foto.de/diatomeen-mit-rheinberg-filter.html, via Wikimedia Commons.

(via afro-dominicano)