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Posts tagged "microscopy"


3D co-culture used to create a microvascular niche. Seen above are human umbilical vein endothelial cells (red immunostaining of CD31), lung fibroblasts expressing alpha-smooth muscle actin (cyan), and T4-2 breast cancer cells (green).

Weigelt & Bissell. (2014) The need for complex 3D culture models to unravel novel pathways and identify accurate biomarkers in breast cancer, Advanced Drug Delivery Reviews.


The Worm Wagon

The top image in this trio shows a close up of an adult Trichuris muris, a whipworm parasite. Here the worm is seen under an electron microscope but more commonly this type of worm is seen taking residence in the large intestine of its host. 

In the second image you can see illustrations of Schistosoma mansoni by Paul Evans © 2012. This parasite lives in the blood and lays thousands of eggs which result in tissue damage and even death.

BBSRC-funded Sheena Cruickshank (centre of picture) and Professor Kathryn Else (right), are lecturers at The University of Manchester who specialise in studying parasites. Both are co-founders, with Dr Jo Pennock (left), of the outreach activity called The Worm Wagon: an exhibition that is part of the BBSRC’s 20th Anniversary Festival. This exhibit will focus on explaining how people catch infections and the global significance of these infections.

When not on the Worm Wagon their day to day research tries to understand the biology and immunology of parasite infection. Part of Sheena’s research is finding markers we can use to help diagnose patients who respond badly to infection and those who don’t. Professor Else concentrates more on vaccine research and how the damage caused by infection is regulated.

This research is vital considering the biggest killer of people under 50 is infection.

Images of Trichuris muris from Uta Rossler, Richard Grencis and Toby Starborg FLS, UoM.

Image of researchers by Mark Waugh, UoM.

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(via science-junkie)



Pictured above are the three winners of the 2013 GE Healthcare Cell Imaging Competition.


13th Prize - Dr Michael Nelson and Samantha Smith

University of Alabama at Birmingham, Birmingham, Alabama, USA
Specimen: Mouse vertebra section (200x)
Technique: Focus Stacking


Top 5 misconceptions about evolution: A guide to demystify the foundation of modern biology.

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Drosophila Heart by Girish C. Melkani

"Amyloid-like inclusions have been associated with Huntington’s disease, and patients exhibit a high incidence of cardiovascular events. Melkani and colleagues generated a Drosophila (fruit fly) model of cardiac amyloidosis. It displays accumulation of mutant Huntingtin aggregates and oxidative stress in myocardial cells upon heart-specific expression of Huntingtin protein fragments with disease-causing poly-glutamine repeats. Using genetic manipulation, the authors showed that modulation of both protein unfolding, and oxidative stress pathways, is required to ameliorate the detrimental mutant Huntingtin defects. The image shows reduced and disorganized myosin- (pink) and actin- (cyan) containing myofibrils along with mutant Huntingtin positive aggregates (green) in the heart."

(via kenobi-wan-obi)


Rat Kidney

Confocal laser scanning microscopy of rat kidney.

Tiles, stitched together with ZEN software to generate hi-res image.



Mr. Brent Bill

Burnsville, MN, USA
Specimen: Zebrafish Embryo
Technique: Confocal


Echiniscus mediantus (tardigrade, water bear), in various states of movement

Technique : Darkfield

Martin Mach

Mikrobiologische Vereinigung München e.V. (MVM) München, Bavaria, Germany

(via kenobi-wan-obi)


Primary mammary epithelium in 3D Matrigel culture.

The mammary gland, which produces milk, is composed of a dense network of ducts that gradually forms after birth through a complex process of budding, invasion, and branching. At birth, the system is a rudimentary duct tree, but in response to hormones, cells in the ducts proliferate and migrate, allowing the ducts to elongate and invade through the mesenchyme layer of mammary tissue into the mammary fat pad, where they then begin to branch. Puberty brings further structural changes to the system of ducts, whereas pregnancy induces the formation of alveolar structures within the ducts for milk production.

Credit: Andrew J. Ewald, Johns Hopkins University.


A micrograph of a diatom with Rheinberg illumination.

Source: Frank Fox,, via Wikimedia Commons.

(via kenobi-wan-obi)


Taking out the defender

by Maria Alhede and Thomas Bjarnsholt, University of Copenhagen

The in vivo interaction between a Pseudomonas aeruginosa biofilm, on a silicone implant, and the responding polymorphonuclear leukocytes.

Image: SEM imaging depicts the interaction at day 1 post insertion of the implant in the peritoneal cavity of a mouse. The leukocytes (yellow) are damaged with obvious cavities in the cell membrane and killed by the bacteria (cyan) following contact with the biofilm. The SEM image was pseudo colored in Photoshop CS5 using a Wacom Cintiq 24HD, by Michael Larsen.

Click here to learn more about scanning electron microscopy (SEM) by Carl Zeiss.




Dr. Jan Michels

Christian-Albrechts-Universität zu Kiel
Institute of Zoology, Functional Morphology and Biomechanics
Kiel, Alberta, Germany

Subject Matter:

Adhesive pad on a foreleg of a ladybird beetle (Coccinella septempunctata)


Confocal Autofluorescence


Nikon Small World Contest 2013
Honorable Mention: A 200x view of the radula (rasping organ) of the mollusc Buccinum undatum (Common Whelk), by Dr. David Maitland, from Feltwell, Norfolk, UK. (Dr. David Maitland)


Pearceite, an uncommon silver mineral, in beautiful hexagonal crystals, from a copper mine in Spain. Reflected Light, Stereomicroscopy at 100X

(via LiveScience)