Science is the poetry of Nature.







Contributing Authors

Scientists Report First Success in Cloning Human Stem Cells

It’s been 17 years since Dolly the sheep was cloned from a mammary cell. And now scientists applied the same technique to make the first embryonic stem cell lines from human skin cells.

Ever since Ian Wilmut, an unassuming embryologist working at the Roslin Institute just outside of Edinburgh stunned the world by cloning the first mammal, Dolly, scientists have been asking – could humans be cloned in the same way? Putting aside the ethical challenges the question raised, the query turned out to involve more wishful thinking than scientific success. Despite the fact that dozens of other species have been cloned using the technique, called nuclear transfer, human cells have remained stubbornly resistant to the process.

Until now. Shoukhrat Mitalipov, a professor at Oregon Health & Science University and his colleagues report in the journal Cell that they have successfully reprogrammed human skin cells back to their embryonic state. The purpose of the study, however, was not to generate human clones but to produce lines of embryonic stem cells. These can develop into muscle, nerve, or other cells that make up the body’s tissues. The process, he says, took only a few months, a surprisingly short period to reach such an important milestone.

Nuclear transfer involves inserting a fully developed cell – in Mitalipov’s study, the cells came from the skin of fetuses – into the nucleus of an egg, and then manipulating the egg to start dividing, a process that normally only occurs after it has been fertilized by a sperm. After several days, the ball of cells that results contains a blanket of embryonic stem cells endowed with the genetic material of the donor skin cell, which have the ability to generate every cell type from that donor. In Dolly’s case, those cells were allowed to continue developing into an embryo that was then transferred to a ewe to produce a cloned sheep. But Mitalipov says his process with the human cells isn’t designed to generate a human clone, but rather just to create the embryonic stem cells. These could then be manipulated to create heart, nerve or other cells that can repair or treat disease.

“I think this is a really important advance,” says Dieter Egli, an investigator at the New York Stem Cell Foundation. “I have a very high confidence that versions of this technique will work very well; it’s something that the field has been waiting for.” Egli is among the handful of scientists who have been working to perfect the technique with human cells and in 2011, succeeded in producing human stem cells, but with double the number of chromosomes. In 2004, Woo Suk Hwang, a veterinary scientist at Seoul National University, claimed to have succeeded in achieving the feat, but later admitted to faking the data. Instead of generating embryonic stem cell lines via nuclear transfer, Hwang’s group produced the stem cells from days-old embryos, a technique that had already been established by James Thomson at University of Wisconsin in 1998.

Full Article

  1. le-science reblogged this from scinerds
  2. dieautismdie reblogged this from slip-inside-the-eye-of-your-mind
  3. slip-inside-the-eye-of-your-mind reblogged this from scinerds
  4. passacaglia05 reblogged this from science-junkie
  5. sengeiori reblogged this from puets
  6. quantumwobbles reblogged this from lantean
  7. eamusadcaelum reblogged this from lantean
  8. lantean reblogged this from nerdosaurusvexed
  9. jmamba reblogged this from scinerds
  10. firecleanses reblogged this from scinerds
  11. nerdosaurusvexed reblogged this from milenadaniels
  12. unspeakableact reblogged this from stillanothermile
  13. my-peace-of-mind reblogged this from scinerds
  14. polymethodic reblogged this from ajora
  15. ajora reblogged this from we-are-star-stuff
  16. gwenhwyfaraway reblogged this from afro-dominicano
  17. spacecase138 reblogged this from we-are-star-stuff
  18. sailorgray reblogged this from scinerds
  19. andthenisank reblogged this from sifu-kisu
  20. flaymeformypleasure reblogged this from science-junkie
  21. maliciastarling reblogged this from afro-dominicano
  22. superiorvintage reblogged this from thescienceofreality
  23. bkwormdeb reblogged this from science-junkie
  24. tatrtotz reblogged this from afro-dominicano
  25. hatsandfruit reblogged this from nbhcannibal
  26. apstem reblogged this from scinerds
  27. savetheplanarians reblogged this from scinerds
  28. juvenile-sage reblogged this from sifu-kisu
  29. carlosison reblogged this from we-are-star-stuff
  30. gusios reblogged this from puets
  31. puets reblogged this from liimperatrice
  32. liimperatrice reblogged this from science-junkie
  33. electrical-potential reblogged this from starsandboulevards
  34. crashaid reblogged this from science-junkie