Science is the poetry of Nature.







Contributing Authors

Scientists map protein that creates antibiotic resistance

Japanese researchers have determined the detailed molecular structure of a protein that rids cells of toxins, but can also reduce the effectiveness of some antibiotics and cancer drugs by kicking them out of the cells they are targeting.

The scientists have also identified a molecule that can thwart the activity of the protein, one of a class known as multidrug and toxic compound extrusion transporters (MATEs) that are found in cell membranes. The discovery suggests new approaches to combat antibiotic resistance and boost the power of cancer therapies, the team reports today in Nature.

Previous efforts to identify compounds that block MATE transporters have been unsuccessful, partly because researchers had a poor understanding of how these proteins work. But in the past three years scientists have made some progress mapping the transporters’ detailed architecture. Two different labs have already revealed the structures of two bacterial MATE proteins, suggesting a mechanism by which the proteins extrude toxins from cells.

“I think this is a major step forward,” says Hendrik Van Veen, a pharmacologist at the University of Cambridge, UK. “They have a direct mechanism of how the protons change the shape of the cavity.”

Full Article

  1. curiousmiles reblogged this from afro-dominicano
  2. wordtoxo reblogged this from scinerds
  3. theheartmaybestrong reblogged this from thescienceofreality
  4. wolfbearsnake reblogged this from daddyjaybird
  5. dead--and--alive reblogged this from scinerds
  6. imyourdestinymotherfucker reblogged this from daddyjaybird
  7. daddyjaybird reblogged this from scinerds
  8. theanalyzersfanfics reblogged this from polymethodic
  9. polymethodic reblogged this from ajora
  10. ajora reblogged this from fyeahmedlab
  11. science-boner reblogged this from thescienceofreality
  12. thepiratedragon reblogged this from thescienceofreality
  13. wolf-of-death-valley reblogged this from godlessgeekblog
  14. mmartist91 reblogged this from thescienceofreality
  15. downslide reblogged this from aguantame
  16. love-is-ours-to-make reblogged this from neurotoxicsquirrel
  17. anticristosuperstar reblogged this from thescienceofreality
  18. medusainwinter reblogged this from thescienceofreality
  19. george-allan reblogged this from thescienceofreality
  20. neurotoxicsquirrel reblogged this from aguantame
  21. aguantame reblogged this from paradoxknight
  22. paradoxknight reblogged this from thescienceofreality
  23. godlessgeekblog reblogged this from thescienceofreality